Teneligliptinhydrobromide hydrate has been investigated for the treatment of Type 2 Diabetes Mellitus.This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids. It is a long-acting, orally bioavailable, pyrrolidine-based inhibitor of dipeptide peptidase 4 (DPP-4), with hypoglycemic activity. Teneligliptin may also reduce plasma triglyceride levels through a sustained increase in GLP-1 levels. It is vast growing molecule in Indian market.
TeneligliptinHydrobromide Hydrate falls under the Anti-Diabetic Category.
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Teneligliptin acts on Incretin hormones, namely glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released from enteroendocrine cells and enhance insulin secretion.Incretins are rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4), and have a very short half-life (t1/2) as a result. DPP-4 inhibitors increase the levels of active GLP-1 and GIP by inhibiting DPP-4 enzymatic activity; thus, in patients with diabetes, these inhibitors improve hyperglycemia in a glucose-dependent manner by increasing serum insulin levels and decreasing serum glucagon levels. Therefore, incretin-related agents such as DPP-4 inhibitors are promising drugs that can decrease glucose fluctuations in diabetic patients and have emerged as a new class of antidiabetic.