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Luliconazole

LULICONAZOLE

 

General Information:

Luliconazole, trade names Luzu among others, is an imidazole antifungal medication. As a 1% topical cream, It is indicated for the treatment of athlete's foot, jock itch, and ringworm caused by dermatophytes such as Trichophyton rubrum, Microsporumgypseum[2] and Epidermophyton floccosum.[1]Therapeutic Category:

Luliconazole falls under the Anti –Fungal drugs category.

 

Primary Characterstics:

IUPAC Name:


(2E)-2-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile

Molecular           Formula:
C14H9Cl2N3S2

Molecular Weight:

354.3 g/mol

Molecular Structure:

 

Mechanism of Action:

Luliconazole is an antifungal that belongs to the azole class. Although the exact mechanism of action against dermatophytes is unknown, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol.