Citicoline (CDP-choline; cytidine 5'-diphosphocholine) is a novel nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction shows promise of clinical efficacy in elderly patients with cognitive deficits, inefficient memory, and early-stage Alzheimer's disease. Citicoline has also been investigated as a therapy in stroke patient. Despite it was approved in some countries for treatment Traumatic Brain Injury (TBI), the use of this drug for acute TBI seems to have no field of support anymore, whereas it may have some benefits in improving the neuro-cognitive state in chronic TBI patients. It's also recommended to keep in mind acute interventions like Psychological First Aid (PFA) during acute TBI management. Citicoline plays several important roles in human physiology, including enhancement of structural integrity and signaling for cell membranes, support of acetylcholine synthesis, and synthesis of betaine, a methyl donor. The precise mechanism of action of Citicoline to treat disease is unknown, but was confirmed, that drug might increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. In addition, was shown, that citicoline modulates phospholipids metabolism and neurotransmitter levels and appears to improve cognition in some central nervous system disorders such as bipolar disorder and cocaine dependence. Bipolar disorder is associated with the highest rates of substance abuse of any psychiatric disorder. Cocaine use is particularly common in patients with bipolar disorder.
Citicolin Sodium falls under the Central stimulant/ Nootropic agent drugs category.
Mechanism of Action:
The primary mechanism of action for Citicoline is as a source of Choline.
Choline is a nutrientsimilar to the B Vitamins that is necessary for the brain to be able to make the acetylcholine neurotransmitter. However, the vast majority of the population does not get the recommended amount of choline form their diet which can lead to mental impairment even with minor deﬁciencies. Citicoline can help to supplement the amount of choline in your bloodstream which them promotes greater acetylcholine production. What is most interested about Citicoline is that it has proven more eﬀective at increasing brainpowerthan taking equivalent amounts of choline supplements
. This is because Citicoline is actually more bioavailable and a closer precursor to acetylcholine.After taking a Citicoline dosage, this compound is absorbed into the bloodstream fairly quickly and then crosses the blood-brain barrier, reaching the brain. The two main components of the supplement, cytidine and choline, are broken down and then widely distributed. As it becomes incorporated into phospholipids it helps to activate their continued biosynthesis.A number of diﬀerent neurotransmitters and brain chemicals are also aﬀected by Citicoline. It acts as a precursor to Acetylcholine and helps to inﬂuence a number of cognitive processes through this action. Dopamine and Norepinephrine levels are also increased throughout the central nervous system. This may also be why many users report their overall stress levels decreaseand a feeling of general well-being to be improved while using this supplement. Citicoline may also help to protect the brain. This includes the possible activation of a number of anti-oxidants. This helps to rid the brain of a number of poisons and toxins, improving overall health. The increase in phospholipid metabolism is also thought to help aid in this brain protection eﬀect, keep the individual cell membranes better able to communicate with one another.