The name of the company has been changed from Laurel Organics Limited to Kimia Biosciences Limited with effect from 04-01-2019 pursuant to the Scheme of Arrangement for Amalgamation of Kimia Biosciences Limited-Transferor Company-with Laurel Organics Limited -Transferee Company-as per the approval and Order of Honrable NCLT Chandigarh.

Acotiamide Hydrochloride Hydrate



General Information:

Acotiamide HydrochlorideHydrate,aprokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

Therapeutic Category:

Acotiamide HydrochlorideHydrate falls under the Gastrointestinal Agent.


Primary Characterstics:



Molecular Formula:

Molecular Weight:

541.1 g/mol

Molecular Structure:



Mechanism of Action:

·        Acotiamide Hydrochloride Hydrate, an AChE inhibitor, enhanced acetylcholine (ACh)-induced contraction and motility of the gastric antrum and body.

·        Acotiamide Hydrochloride Hydrate inhibited human AChE with mixed pattern (Ki1 = 0.61 ± 0.03 µM, Ki2 = 2.7 ± 0.2 µM, and IC50 = 3 µM) and suppressed the degradation of ACh released from cholinergic nerve terminals.

·        The AChE inhibitory effect of acotiamide almost disappeared by dialysis, which was shown to be reversible.

·        AcotiamideHydrochloride Hydrate did not show a high affinity to the muscarinic M1, M2, M3, dopamine D2S and serotonin 5-HT4 receptors involving in the regulation of gastrointestinal motility.